Across TCGA patient cohorts, MAFF mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAFF-associated genes across cancer lineages are GAPDH, MEK1, and MSH2. Each is linked with MAFF in more than 1 cancer types. Because this analysis shows association rather than direction, both MAFF-to-partner and partner-to-MAFF results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAFF→partner) and Y-score (partner→MAFF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.578	+2.999	.025	.035	3	1
UCEC	MEK1 →	+0.474	+2.321	.007	.034	3	1
UCEC	MSH2 →	-0.367	-2.312	<.001	.034	3	1
UCEC	N-Ras →	-0.150	-2.446	.009	.020	3	1
UCEC	p62 Lck ligand →	+0.385	+3.179	.014	.010	3	1
UCEC	beta-Catenin →	+0.539	+2.459	.027	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

MAFF survival (RNA) · tumor vs normal (RNA) · all MAFF data types