MAFA-AS1

Across TCGA pan-cancer cohorts, MAFA-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated MAFA-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MAFA-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MAFA-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LUAD show a favorable association.

ACC, UCEC, and COAD are the cancer types where MAFA-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.658	0.924	<.001	107	view →
UCEC	DFS	Median	All	0.790	0.884	<.001	92	view →
COAD	OS	Tertile	All	0.412	0.807	<.001	91	view →
BRCA	OS	Median	All	0.975	0.949	.001	87	view →
KIRC	DFS	Quartile	All	0.641	0.858	<.001	56	view →
UVM	OS	Median	All	0.407	1.000	.001	54	view →
LGG	DFS	Median	All	0.656	0.799	<.001	53	view →
LUAD	OS	Quartile	II,III,IV	0.806	0.661	.007	43	view →
DLBC	OS	Quartile	All	0.507	0.831	.015	38	view →
OV	OS	Median	All	0.271	0.371	.005	36	view →
LIHC	DFS	Quartile	All	0.373	0.619	<.001	35	view →
STAD	DFS	Tertile	III,IV	0.420	0.659	.003	31	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

MAFA-AS1–ACC (OS)

Open the ACC breakdown →