MAFA-AS1

Across TCGA pan-cancer cohorts, MAFA-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MAFA-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MAFA-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAFA-AS1 is over-expressed in tumor, although a few such as PRAD show the opposite, repressed pattern.

HNSC, KICH, and LUSC are the cancer types where MAFA-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAFA-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	+0.905	<.001	9	view →
KICH	All	II,III,IV	+1.405	<.001	8	view →
LUSC	Male	All	+1.238	<.001	6	view →
UCEC	All	All	+0.637	.001	6	view →
BRCA	All	II,III,IV	+0.553	<.001	6	view →
LUAD	Female	All	+0.542	<.001	6	view →
LIHC	Male	All	+0.930	<.001	5	view →
CHOL	All	II,III,IV	+1.535	<.001	4	view →
COAD	All	All	+0.184	.008	4	view →
KIRC	Male	All	+0.151	.011	4	view →
ESCA	Female	All	+0.760	.035	2	view →
BLCA	Male	All	+0.520	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MAFA-AS1–HNSC

Open the HNSC breakdown →