MAEL

Across TCGA patient cohorts, MAEL protein abundance is significantly associated with the RNA expression of many other genes, with 141 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MAEL-associated genes across cancer lineages are DPH5, RPL5, and RALY. Each is linked with MAEL in more than 1 cancer types. Because this analysis shows association rather than direction, both MAEL-to-partner and partner-to-MAEL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MAEL versus DPH5 in LSCC, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAEL→partner) and Y-score (partner→MAEL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DPH5 →	+1.383	+1.010	<.001	.008	3	1
LSCC	RPL5 →	+0.968	+0.821	.007	.006	3	1
LSCC	RALY →	+0.759	+0.821	<.001	.006	3	1
LSCC	COX7C →	+0.773	+0.873	.008	.009	3	1
LSCC	THEM6 →	+1.094	+0.708	.001	.005	3	1
LSCC	MAP7 →	+1.359	+1.010	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 141 associations by consensus.

MAEL vs DPH5 — LSCC

Explore this scatter interactively →