MAEL

Across TCGA pan-cancer cohorts, MAEL RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of MAEL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MAEL RNA is repressed in tumor relative to normal tissue. In most cancer types MAEL is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, BLCA, and BRCA are the cancer types where MAEL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAEL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−1.148	<.001	11	view →
BLCA	All	III,IV	−0.436	.001	8	view →
BRCA	Female	II,III,IV	+0.263	.001	6	view →
LIHC	All	All	+0.655	<.001	5	view →
UCEC	All	III,IV	−0.250	.021	4	view →
READ	All	All	−0.626	.008	3	view →
LUAD	Male	II,III,IV	+0.396	.001	3	view →
CHOL	All	All	+0.582	.027	1	view →
THCA	All	All	−0.077	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

MAEL–KICH

Open the KICH breakdown →