MAEL

Across TCGA patient cohorts, MAEL mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAEL-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and Lck. Each is linked with MAEL in more than 2 cancer types. Because this analysis shows association rather than direction, both MAEL-to-partner and partner-to-MAEL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MAEL-low versus MAEL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAEL→partner) and Y-score (partner→MAEL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.758	+2.201	<.001	<.001	3	3
UCEC	eIF4E →	+0.198	+2.713	.004	.003	3	2
UCEC	Lck →	+0.149	+1.321	.027	.029	3	2
UCEC	MEK1 →	+0.413	+2.584	<.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.124	-2.102	.012	.016	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.333	-1.906	.027	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Caspase-7-cleavedD198 by MAEL expression — UCEC

Explore this box plot interactively →