MAEL

Across TCGA cell cohorts, MAEL mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MAEL-associated genes across cancer lineages are HBZ, SSTR5, and KRTAP4-6. Each is linked with MAEL in more than 1 cancer types. Because this analysis shows association rather than direction, both MAEL-to-partner and partner-to-MAEL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HBZ grouped by MAEL-low versus MAEL-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAEL→partner) and Y-score (partner→MAEL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HBZ →	+0.076	+3.353	.001	.004	3	1
SKIN	SSTR5 →	+0.231	+2.845	.004	.009	3	1
SKIN	KRTAP4-6 →	+0.025	+4.000	<.001	<.001	3	1
SKIN	CT45A7 →	+0.273	+3.297	<.001	.002	3	1
SKIN	SLAMF6 →	+0.036	+3.115	<.001	.008	2	1
SKIN	GOLGA8J →	+0.045	+3.295	.002	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

HBZ by MAEL expression — SKIN

Explore this box plot interactively →