MAEL

Across TCGA cell cohorts, MAEL mutation is significantly associated with the mutation status of many other genes, with 1,705 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAEL-associated genes across cancer lineages are MRGBP, GRHL2, and MBNL1. Each is linked with MAEL in more than 2 cancer types. Because this analysis shows association rather than direction, both MAEL-to-partner and partner-to-MAEL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRGBP grouped by MAEL-low versus MAEL-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAEL→partner) and Y-score (partner→MAEL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MRGBP →	+4.560	+4.870	<.001	<.001	1	3
BLOOD_Leukemia	GRHL2 →	+3.823	+4.430	.001	.001	1	3
SKIN	MBNL1 →	+3.718	+3.053	.006	.006	1	3
BLOOD_Leukemia	COL6A6 →	+2.975	+4.741	<.001	<.001	1	3
LUNG_NSCLC_LUAD	ITGB2 →	+5.772	+5.772	.002	.002	1	3
BLOOD_Leukemia	KHDC4 →	+4.145	+4.635	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,705 associations by consensus.

MRGBP by MAEL expression — BLOOD_Leukemia

Explore this box plot interactively →