MADD

Across TCGA patient cohorts, MADD protein abundance is significantly associated with the RNA expression of many other genes, with 11,629 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MADD-associated genes across cancer lineages are C11orf49, STARD10, and MAPK8IP1. Each is linked with MADD in more than 3 cancer types. Because this analysis shows association rather than direction, both MADD-to-partner and partner-to-MADD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MADD versus C11orf49 in BRCA, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MADD→partner) and Y-score (partner→MADD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C11orf49 →	+0.593	+0.338	<.001	<.001	3	4
BRCA	STARD10 →	+1.651	+0.361	<.001	<.001	3	4
BRCA	MAPK8IP1 →	+1.014	+0.301	<.001	<.001	3	4
OV	MTDHP1 →	+0.665	+0.222	.001	.003	3	3
OV	BRAP →	+0.439	+0.175	.001	.005	3	3
BRCA	MTERF2 →	+0.614	+0.268	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,629 associations by consensus.

MADD vs C11orf49 — BRCA

Explore this scatter interactively →