MADD

Across TCGA pan-cancer cohorts, MADD RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of MADD’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where MADD RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MADD is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

LIHC, THCA, and KICH are the cancer types where MADD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MADD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.073	<.001	9	view →
THCA	All	All	−0.349	<.001	8	view →
KICH	All	All	−0.872	<.001	7	view →
CHOL	All	All	+1.637	<.001	5	view →
STAD	Male	II,III,IV	+1.007	<.001	5	view →
KIRP	Male	All	−0.475	.002	3	view →
HNSC	All	All	+0.276	.011	3	view →
KIRC	Male	II,III,IV	−0.268	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

MADD–LIHC

Open the LIHC breakdown →