MADD

Across TCGA patient cohorts, MADD mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MADD-associated genes across cancer lineages are Cyclin-E2, EGFR_pY1068, and ERK2. Each is linked with MADD in more than 2 cancer types. Because this analysis shows association rather than direction, both MADD-to-partner and partner-to-MADD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by MADD-low versus MADD-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MADD→partner) and Y-score (partner→MADD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-E2 →	+0.157	+3.021	.025	.018	3	3
COAD	EGFR_pY1068 →	-0.337	-3.000	.011	.034	3	3
COAD	ERK2 →	+0.239	+3.169	.002	.018	3	3
UCEC	MEK1 →	+0.321	+2.000	.001	<.001	3	3
UCEC	Shc_pY317 →	-0.142	-1.836	<.001	.001	3	3
UCEC	Cyclin-B1 →	+0.359	+1.273	.023	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Cyclin-E2 by MADD expression — STAD

Explore this box plot interactively →