MADD

Across TCGA cell cohorts, MADD mutation is significantly associated with the RNA expression of many other genes, with 673 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MADD-associated genes across cancer lineages are GAS2L1, OR10K1, and CRACD. Each is linked with MADD in more than 2 cancer types. Because this analysis shows association rather than direction, both MADD-to-partner and partner-to-MADD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAS2L1 grouped by MADD-low versus MADD-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MADD→partner) and Y-score (partner→MADD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GAS2L1 →	+0.767	+2.459	.002	.006	3	3
LUNG_NSCLC_LUAD	OR10K1 →	+0.003	+2.777	<.001	.004	3	2
BLOOD_Leukemia	CRACD →	+1.274	+3.321	.004	.005	3	2
LARGE_INTESTINE	PPP2R5D →	+0.558	+2.649	.001	.001	3	2
LARGE_INTESTINE	MRPL34 →	+0.418	+2.404	.002	.004	3	2
LARGE_INTESTINE	RSAD1 →	+0.584	+2.364	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 673 associations by consensus.

GAS2L1 by MADD expression — LARGE_INTESTINE

Explore this box plot interactively →