MADCAM1

Across TCGA patient cohorts, MADCAM1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,245 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MADCAM1-associated genes across cancer lineages are LGALS2, CNIH1, and SEC23A. Each is linked with MADCAM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MADCAM1-to-partner and partner-to-MADCAM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MADCAM1 versus LGALS2 in PDAC, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MADCAM1→partner) and Y-score (partner→MADCAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LGALS2 →	+0.781	+0.582	.006	.003	3	1
PDAC	CNIH1 →	-0.320	-0.854	.006	<.001	3	1
PDAC	SEC23A →	-0.510	-1.073	.001	<.001	3	1
PDAC	PFDN4 →	-0.350	-0.777	.003	.001	3	1
PDAC	TCFL5 →	-0.387	-0.822	.007	.005	3	1
PDAC	PPP1R16B →	+0.618	+0.741	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,245 associations by consensus.

MADCAM1 vs LGALS2 — PDAC

Explore this scatter interactively →