MADCAM1

Across TCGA pan-cancer cohorts, MADCAM1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of MADCAM1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MADCAM1 RNA is repressed in tumor relative to normal tissue. In most cancer types MADCAM1 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, KIRP, and LIHC are the cancer types where MADCAM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MADCAM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−1.684	<.001	12	view →
KIRP	All	II,III,IV	+0.518	.002	6	view →
LIHC	All	All	+0.303	<.001	5	view →
READ	All	All	−1.491	.001	4	view →
CHOL	All	All	+0.665	.001	3	view →
BLCA	Male	All	+0.547	.048	2	view →
PRAD	All	All	+0.263	<.001	2	view →
KICH	All	IV	+0.262	.016	2	view →
THCA	All	All	−0.379	.018	1	view →
KIRC	Female	All	+0.111	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

MADCAM1–COAD

Open the COAD breakdown →