MADCAM1

Across TCGA patient cohorts, MADCAM1 mutation is significantly associated with the RNA expression of many other genes, with 821 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MADCAM1-associated genes across cancer lineages are RNU6-961P, RNU6-718P, and RBM12B-AS1. Each is linked with MADCAM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MADCAM1-to-partner and partner-to-MADCAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-961P grouped by MADCAM1-low versus MADCAM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MADCAM1→partner) and Y-score (partner→MADCAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-961P →	+0.104	+4.475	<.001	.003	3	2
UCEC	RNU6-718P →	+0.204	+4.002	<.001	.001	3	2
UCEC	RBM12B-AS1 →	+0.568	+3.711	.002	<.001	3	1
SKCM	MIR6731 →	+1.243	+4.221	<.001	.003	3	1
LUSC	RNU6-1090P →	+0.422	+7.924	<.001	.008	3	1
LUSC	RNU7-105P →	+0.566	+7.924	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 821 associations by consensus.

RNU6-961P by MADCAM1 expression — UCEC

Explore this box plot interactively →