MADCAM1

Across TCGA patient cohorts, MADCAM1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MADCAM1-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and Ku80. Each is linked with MADCAM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MADCAM1-to-partner and partner-to-MADCAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MADCAM1-low versus MADCAM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MADCAM1→partner) and Y-score (partner→MADCAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.119	-2.973	.014	.035	3	1
UCEC	A-Raf_pS299 →	-0.163	-2.459	.004	.020	3	1
UCEC	Ku80 →	+0.257	+2.820	.024	.035	3	1
UCEC	MEK1 →	+0.492	+3.584	.005	.002	3	1
UCEC	Rab25 →	-0.455	-2.459	.004	.020	3	1
UCEC	STAT3_pY705 →	-0.415	-2.459	.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

14-3-3_beta by MADCAM1 expression — UCEC

Explore this box plot interactively →