MADCAM1

Across TCGA cell cohorts, MADCAM1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MADCAM1-associated genes across cancer lineages are RFPL3, OR6Q1, and CD300H. Each is linked with MADCAM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MADCAM1-to-partner and partner-to-MADCAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFPL3 grouped by MADCAM1-low versus MADCAM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MADCAM1→partner) and Y-score (partner→MADCAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RFPL3 →	+0.040	+4.095	.001	.009	3	1
LARGE_INTESTINE	OR6Q1 →	+0.022	+5.022	<.001	.002	3	1
LARGE_INTESTINE	CD300H →	+0.033	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

RFPL3 by MADCAM1 expression — LARGE_INTESTINE

Explore this box plot interactively →