MAD2L2

Across TCGA cell cohorts, MAD2L2 mutation is significantly associated with the mutation status of many other genes, with 1,146 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAD2L2-associated genes across cancer lineages are MAPKAPK5, HPS1, and MTPAP. Each is linked with MAD2L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAD2L2-to-partner and partner-to-MAD2L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPKAPK5 grouped by MAD2L2-low versus MAD2L2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAD2L2→partner) and Y-score (partner→MAD2L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAPKAPK5 →	+2.893	+3.222	.003	.003	1	2
LARGE_INTESTINE	HPS1 →	+2.893	+3.222	.003	.003	1	2
LARGE_INTESTINE	MTPAP →	+2.407	+2.886	.008	.008	1	2
LARGE_INTESTINE	TBX2 →	+3.630	+3.630	.001	.001	1	2
LARGE_INTESTINE	TUT7 →	+1.951	+3.015	.006	.006	1	2
LARGE_INTESTINE	SLC24A1 →	+2.407	+2.886	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,146 associations by consensus.

MAPKAPK5 by MAD2L2 expression — LARGE_INTESTINE

Explore this box plot interactively →