MAD2L1BP

Across TCGA pan-cancer cohorts, MAD2L1BP mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MAD2L1BP data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MAD2L1BP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MAD2L1BP expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, LSCC, and HNSC are the cancer types where MAD2L1BP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	III,IV	1.000	0.287	.020	16	view →
LSCC	OS	Quartile	All	0.882	0.660	.015	6	view →
HNSC	OS	Median	II,III,IV	1.000	0.949	.019	5	view →
GBM	DFS	Quartile	All	0.462	0.275	.011	4	view →
LUAD	DFS	Median	III,IV	0.709	0.285	.026	4	view →
PDAC	DFS	Quartile	II,III,IV	0.440	0.792	.009	3	view →
CCRCC	DFS	Quartile	II,III,IV	0.842	0.262	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MAD2L1BP–UCEC (DFS)

Open the UCEC breakdown →