MACROH2A1

Across TCGA cell cohorts, MACROH2A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,198 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MACROH2A1-associated GO terms across cancer lineages are Cell cycle checkpoint signaling, Negative regulation of cell cycle phase transition, and Mitotic chromosome condensation. Each is linked with MACROH2A1 in more than 14 cancer types. Because this analysis shows association rather than direction, both MACROH2A1-to-partner and partner-to-MACROH2A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell cycle checkpoint signaling grouped by MACROH2A1-low versus MACROH2A1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MACROH2A1→partner) and Y-score (partner→MACROH2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cell cycle checkpoint signaling →	+0.092	+1.017	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle phase transition →	+0.083	+0.851	<.001	.002	3	15
BONE	Mitotic chromosome condensation →	+0.163	+0.739	.003	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Mitotic cell cycle checkpoint signaling →	+0.114	+1.020	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	DNA damage checkpoint signaling →	+0.080	+0.886	.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	DNA integrity checkpoint signaling →	+0.088	+0.762	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,198 associations by consensus.

Cell cycle checkpoint signaling by MACROH2A1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →