MACROD2

Across TCGA patient cohorts, MACROD2 mutation is significantly associated with the RNA expression of many other genes, with 2,487 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MACROD2-associated genes across cancer lineages are PINX1, TEX36-AS1, and RNU6-740P. Each is linked with MACROD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MACROD2-to-partner and partner-to-MACROD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PINX1 grouped by MACROD2-low versus MACROD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MACROD2→partner) and Y-score (partner→MACROD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PINX1 →	+0.520	+2.148	<.001	<.001	3	3
SKCM	TEX36-AS1 →	+0.013	+2.961	<.001	.006	3	3
SKCM	RNU6-740P →	+0.094	+4.147	<.001	<.001	3	3
UCEC	BUB3 →	+0.432	+2.981	<.001	<.001	3	2
UCEC	SKA1 →	+0.646	+3.606	<.001	.001	3	2
UCEC	RDH13 →	+0.323	+1.818	.009	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,487 associations by consensus.

PINX1 by MACROD2 expression — UCEC

Explore this box plot interactively →