MACROD2

Across TCGA pan-cancer cohorts, MACROD2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MACROD2 data layer compared with 11 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MACROD2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MACROD2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

HNSC, LUSC, and UCS are the cancer types where MACROD2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	IV	0.457	0.184	<.001	88	view →
LUSC	DFS	Tertile	II,III,IV	0.644	0.800	.002	77	view →
UCS	DFS	Median	IV	0.952	0.367	.001	60	view →
DLBC	OS	Median	All	0.386	0.951	.008	32	view →
LGG	OS	Median	All	0.932	0.853	<.001	22	view →
UCEC	DFS	Quartile	II,III,IV	0.772	0.876	.017	20	view →
CESC	OS	Quartile	IV	0.796	0.137	.001	18	view →
KIRC	DFS	Median	IV	0.608	0.281	.003	16	view →
KIRP	OS	Quartile	III,IV	0.146	0.602	.014	15	view →
SARC	DFS	Quartile	All	0.822	0.543	.003	15	view →
CHOL	DFS	Tertile	All	0.677	0.203	.017	15	view →
COAD	DFS	Median	All	0.629	0.742	.013	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MACROD2–HNSC (OS)

Open the HNSC breakdown →