MACROD2

Across TCGA cell cohorts, MACROD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,193 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible MACROD2-associated GO terms across cancer lineages are Peptidyl-glutamate ADP-deribosylation, Pyrimidine nucleoside catabolic process, and Positive regulation of triglyceride storage. Each is linked with MACROD2 in more than 9 cancer types. Because this analysis shows association rather than direction, both MACROD2-to-partner and partner-to-MACROD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-glutamate ADP-deribosylation grouped by MACROD2-low versus MACROD2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MACROD2→partner) and Y-score (partner→MACROD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Peptidyl-glutamate ADP-deribosylation →	-0.193	-0.674	.002	.001	2	10
BREAST	Pyrimidine nucleoside catabolic process →	-1.152	-0.809	<.001	.001	3	6
LUNG_SCLC	Positive regulation of triglyceride storage →	-1.019	-1.365	.006	.006	3	6
UPPER_AERODIGESTIVE_TRACT	Cardiolipin acyl-chain remodeling →	+0.069	+0.447	.005	.003	3	6
LUNG_NSCLC_LUAD	Establishment of vesicle localization →	+0.029	+0.830	.001	.006	3	6
BONE	Golgi to endosome transport →	+0.079	+0.818	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,193 associations by consensus.

Peptidyl-glutamate ADP-deribosylation by MACROD2 expression — SOFT_TISSUE

Explore this box plot interactively →