MACROD2

Across TCGA cell cohorts, MACROD2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MACROD2-associated genes across cancer lineages are KRT71, TSPY1, and SLC35G3. Each is linked with MACROD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MACROD2-to-partner and partner-to-MACROD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT71 grouped by MACROD2-low versus MACROD2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MACROD2→partner) and Y-score (partner→MACROD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRT71 →	+0.009	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	TSPY1 →	+0.015	+5.247	<.001	.001	3	1
LARGE_INTESTINE	SLC35G3 →	+0.006	+2.882	<.001	.005	3	1
SKIN	OR10J5 →	+0.013	+4.022	<.001	.006	3	1
SKIN	OR6C74 →	+0.066	+3.632	<.001	.003	3	1
SKIN	HSFX3 →	+0.079	+4.129	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

KRT71 by MACROD2 expression — BLOOD_Lymphoma

Explore this box plot interactively →