MACROD2-IT1

Across TCGA pan-cancer cohorts, MACROD2-IT1 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated MACROD2-IT1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher MACROD2-IT1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MACROD2-IT1 expression acts as an unfavorable survival marker, although some lineages such as UCS show a favorable association.

UCS, COAD, and KICH are the cancer types where MACROD2-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Quartile	III,IV	0.637	0.160	.008	38	view →
COAD	DFS	Tertile	All	0.582	0.712	.010	33	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	27	view →
GBM	DFS	Tertile	All	0.090	0.264	<.001	27	view →
ACC	OS	Tertile	All	0.113	0.822	<.001	27	view →
THCA	OS	Tertile	II,III,IV	0.552	0.918	.009	27	view →
OV	OS	Quartile	IV	0.493	0.807	.004	18	view →
BLCA	DFS	Quartile	All	0.138	0.415	.015	14	view →
TGCT	DFS	Tertile	All	0.678	0.831	.038	12	view →
KIRP	OS	Tertile	III,IV	0.247	0.809	.003	9	view →
SARC	OS	Tertile	All	0.249	0.619	.025	6	view →
LUAD	OS	Quartile	All	0.773	0.852	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

MACROD2-IT1–UCS (DFS)

Open the UCS breakdown →