MACROD2-IT1

Across TCGA pan-cancer cohorts, MACROD2-IT1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MACROD2-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where MACROD2-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MACROD2-IT1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

STAD, THCA, and LUSC are the cancer types where MACROD2-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MACROD2-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	All	+0.093	.007	4	view →
THCA	All	All	−0.024	.001	4	view →
LUSC	All	All	+0.028	.030	2	view →
CHOL	All	All	+0.068	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MACROD2-IT1–STAD

Open the STAD breakdown →