MACROD2-AS1

Across TCGA pan-cancer cohorts, MACROD2-AS1 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated MACROD2-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher MACROD2-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MACROD2-AS1 expression acts as an unfavorable survival marker, although some lineages such as LIHC and OV show a favorable association.

UVM, STAD, and LUSC are the cancer types where MACROD2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.415	0.768	.010	48	view →
STAD	DFS	Quartile	IV	0.109	0.591	.006	31	view →
LUSC	DFS	Tertile	III,IV	0.422	0.685	.013	30	view →
THCA	OS	Tertile	III,IV	0.763	0.935	.033	15	view →
BLCA	DFS	Tertile	All	0.166	0.412	.028	12	view →
LIHC	DFS	Tertile	II,III,IV	0.642	0.260	.008	9	view →
OV	DFS	Median	II,III,IV	0.414	0.348	.036	8	view →
KIRC	DFS	Tertile	All	0.507	0.670	.034	4	view →
BRCA	DFS	Quartile	IV	1.000	0.590	.037	4	view →
ESCA	DFS	Median	II,III,IV	0.424	0.231	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

MACROD2-AS1–UVM (DFS)

Open the UVM breakdown →