MACROD2-AS1

Across TCGA pan-cancer cohorts, MACROD2-AS1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MACROD2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in esophageal carcinoma (ESCA), where MACROD2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types MACROD2-AS1 is over-expressed in tumor, although a few such as ESCA and THCA show the opposite, repressed pattern.

ESCA, BRCA, and THCA are the cancer types where MACROD2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MACROD2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
ESCA	All	All	−0.230	.018	2	view →
BRCA	Female	All	+0.111	.042	2	view →
THCA	All	All	−0.011	.027	2	view →
LIHC	All	All	+0.007	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MACROD2-AS1–ESCA

Open the ESCA breakdown →