Across TCGA pan-cancer cohorts, MACO1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MACO1 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MACO1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated MACO1 expression acts as an unfavorable survival marker.

HNSC, COAD, and UCEC are the cancer types where MACO1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.168	0.628	.004	23	view →
COAD	OS	Median	III,IV	0.056	0.781	<.001	21	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: MACO1 tumor-vs-normal RNA expression · all MACO1 data types