Across TCGA pan-cancer cohorts, MACO1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MACO1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MACO1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MACO1 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.
KIRC, THCA, and BLCA are the cancer types where MACO1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MACO1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.