Across TCGA patient cohorts, MACO1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,475 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MACO1-associated proteins across cancer lineages are RPS6KA1, LYPLA2, and MACO1_S332. Each is linked with MACO1 in more than 4 cancer types. Because this analysis shows association rather than direction, both MACO1-to-partner and partner-to-MACO1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MACO1→partner) and Y-score (partner→MACO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPS6KA1 →	+0.340	+0.483	.001	<.001	3	5
LSCC	LYPLA2 →	+0.294	+0.427	<.001	<.001	3	4
BRCA	MACO1_S332 →	+0.964	+0.454	.002	.009	3	4
OV	MCAM →	+0.483	+0.307	.003	.007	3	4
CCRCC	PLEKHO2_T311 →	-0.362	-0.351	.002	<.001	3	4
PDAC	RNF220 →	+0.316	+0.176	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,475 associations by consensus.

Exploration

MACO1 survival (RNA) · tumor vs normal (RNA) · all MACO1 data types