Across TCGA patient cohorts, MACO1 mutation is significantly associated with the RNA expression of many other genes, with 2,167 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MACO1-associated genes across cancer lineages are C4orf46, OR6K5P, and MIR4309. Each is linked with MACO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MACO1-to-partner and partner-to-MACO1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MACO1→partner) and Y-score (partner→MACO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C4orf46 →	+0.539	+2.732	.001	.003	3	3
READ	OR6K5P →	+0.057	+6.257	<.001	.001	3	2
CESC	MIR4309 →	+0.369	+5.342	<.001	.002	3	2
UCEC	AARSD1 →	+0.307	+1.939	.004	.009	3	2
UCEC	SMIM15P2 →	+0.450	+1.668	.002	.008	3	2
STAD	RNU1-57P →	+0.373	+4.611	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,167 associations by consensus.

Exploration

MACO1 survival (RNA) · tumor vs normal (RNA) · all MACO1 data types