Across TCGA patient cohorts, MACO1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MACO1-associated genes across cancer lineages are MEK1, EGFR_pY1068, and eIF4G. Each is linked with MACO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MACO1-to-partner and partner-to-MACO1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MACO1→partner) and Y-score (partner→MACO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.326	+2.459	.023	.019	3	2
UCEC	EGFR_pY1068 →	-0.304	-2.502	.001	.002	3	1
UCEC	eIF4G →	+0.245	+2.459	.044	.019	3	1
UCEC	ERK2 →	+0.188	+2.000	.012	.029	3	1
UCEC	Gab2 →	+0.278	+2.000	.047	.010	3	1
UCEC	GATA6 →	-0.169	-3.155	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

MACO1 survival (RNA) · tumor vs normal (RNA) · all MACO1 data types