Across TCGA cell cohorts, MACO1 mutation is significantly associated with the RNA expression of many other genes, with 535 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MACO1-associated genes across cancer lineages are LRIT2, PGK2, and OPN1MW2. Each is linked with MACO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MACO1-to-partner and partner-to-MACO1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MACO1→partner) and Y-score (partner→MACO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LRIT2 →	+0.029	+5.415	<.001	.004	3	2
SOFT_TISSUE	PGK2 →	+0.209	+4.930	<.001	.008	3	1
URINARY_TRACT	OPN1MW2 →	+0.015	+4.087	<.001	.009	3	1
URINARY_TRACT	FAM9A →	+0.050	+5.044	<.001	<.001	3	1
URINARY_TRACT	GPX5 →	+0.182	+4.087	.001	.009	3	1
URINARY_TRACT	C4orf51 →	+0.229	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 535 associations by consensus.

Exploration

MACO1 survival (RNA) · tumor vs normal (RNA) · all MACO1 data types