Across TCGA cell cohorts, MACO1 mutation is significantly associated with the mutation status of many other genes, with 2,511 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MACO1-associated genes across cancer lineages are AGBL1, MYH8, and KIAA1217. Each is linked with MACO1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MACO1-to-partner and partner-to-MACO1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MACO1→partner) and Y-score (partner→MACO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AGBL1 →	+3.313	+3.430	.005	.005	1	4
BLOOD_Leukemia	MYH8 →	+3.202	+4.282	<.001	<.001	1	4
SOFT_TISSUE	KIAA1217 →	+5.066	+4.502	.007	.007	1	4
SOFT_TISSUE	ITGB4 →	+3.651	+4.777	.002	.002	1	4
SOFT_TISSUE	GIGYF1 →	+4.066	+5.022	.001	.001	1	4
LARGE_INTESTINE	ELOA →	+2.169	+3.064	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,511 associations by consensus.

Exploration

MACO1 survival (RNA) · tumor vs normal (RNA) · all MACO1 data types