MAB21L4

Across TCGA patient cohorts, MAB21L4 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAB21L4-associated genes across cancer lineages are MAPK_pT202_Y204, MYH11, and YB-1_pS102. Each is linked with MAB21L4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAB21L4-to-partner and partner-to-MAB21L4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by MAB21L4-low versus MAB21L4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAB21L4→partner) and Y-score (partner→MAB21L4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPK_pT202_Y204 →	-0.572	-3.000	.015	.036	3	1
UCEC	MYH11 →	+1.710	+3.459	.002	.005	3	1
UCEC	YB-1_pS102 →	-0.226	-2.321	.015	.035	3	1
UCEC	VEGFR2 →	+0.509	+2.335	<.001	.020	2	1
UCEC	MEK1 →	+0.456	+2.321	.013	.035	1	1
UCEC	Notch1 →	+0.197	+3.459	.005	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MAPK_pT202_Y204 by MAB21L4 expression — UCEC

Explore this box plot interactively →