MAB21L4

Across TCGA pan-cancer cohorts, MAB21L4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MAB21L4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MAB21L4 RNA is repressed in tumor relative to normal tissue. In most cancer types MAB21L4 is over-expressed in tumor, although a few such as HNSC and KIRC show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where MAB21L4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAB21L4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−4.170	<.001	12	view →
KIRC	Male	All	−2.828	<.001	12	view →
KIRP	All	III,IV	−3.608	<.001	11	view →
KICH	Female	II,III,IV	−3.985	<.001	8	view →
LUSC	Female	II,III,IV	−3.174	<.001	8	view →
LUAD	Female	All	−1.680	<.001	8	view →
BRCA	All	II,III,IV	+1.535	<.001	6	view →
THCA	All	All	+0.504	<.001	6	view →
LIHC	All	All	+0.862	.011	3	view →
PAAD	All	All	+2.400	.034	2	view →
BLCA	All	IV	+1.870	.019	2	view →
UCEC	All	All	+1.687	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MAB21L4–HNSC

Open the HNSC breakdown →