LZTS3

Across TCGA patient cohorts, LZTS3 mutation is significantly associated with the RNA expression of many other genes, with 3,150 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LZTS3-associated genes across cancer lineages are RNU6-162P, GTF2IP8, and SRP9P1. Each is linked with LZTS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LZTS3-to-partner and partner-to-LZTS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-162P grouped by LZTS3-low versus LZTS3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LZTS3→partner) and Y-score (partner→LZTS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNU6-162P →	+0.574	+4.859	<.001	<.001	3	2
LUSC	GTF2IP8 →	+0.217	+5.792	<.001	.003	3	2
UCEC	SRP9P1 →	+0.777	+2.740	.001	.003	3	2
UCEC	GP1BA →	+0.591	+2.479	<.001	.001	3	2
UCEC	HEXIM1 →	+0.755	+3.721	<.001	<.001	3	2
UCEC	FANCA →	+0.909	+3.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,150 associations by consensus.

RNU6-162P by LZTS3 expression — STAD

Explore this box plot interactively →