LZTS3

Across TCGA pan-cancer cohorts, LZTS3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated LZTS3 data layer compared with 8 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher LZTS3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LZTS3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LGG show a favorable association.

COAD, THCA, and MESO are the cancer types where LZTS3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.381	0.608	.001	74	view →
THCA	DFS	Tertile	IV	0.442	0.939	<.001	55	view →
MESO	OS	Quartile	All	0.413	0.680	.003	51	view →
HNSC	OS	Median	IV	0.777	0.632	.003	41	view →
ESCA	OS	Quartile	All	0.287	1.000	.006	25	view →
LGG	OS	Median	All	0.930	0.860	<.001	25	view →
SCLC	DFS	Quartile	III,IV	0.291	0.680	.011	24	view →
LUAD	DFS	Median	II,III,IV	0.736	0.551	.017	23	view →
BLCA	DFS	Median	III,IV	0.218	0.481	.002	19	view →
STAD	DFS	Median	IV	0.566	0.169	.006	13	view →
ACC	OS	Quartile	III,IV	1.000	0.632	.013	13	view →
UCEC	OS	Median	IV	0.729	0.250	.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

LZTS3–COAD (DFS)

Open the COAD breakdown →