LZTS3

Across TCGA patient cohorts, LZTS3 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LZTS3-associated genes across cancer lineages are Caspase-7-cleavedD198, C-Raf, and INPP4B. Each is linked with LZTS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LZTS3-to-partner and partner-to-LZTS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by LZTS3-low versus LZTS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LZTS3→partner) and Y-score (partner→LZTS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.730	+2.459	.010	.020	3	2
UCEC	C-Raf →	+0.158	+3.321	.022	.010	3	2
COAD	INPP4B →	-0.448	-2.991	.020	.036	3	1
COAD	Cyclin-E1 →	+0.298	+3.008	.021	.019	3	1
UCEC	ERK2 →	+0.190	+2.459	.041	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.169	-2.446	.038	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Caspase-7-cleavedD198 by LZTS3 expression — UCEC

Explore this box plot interactively →