LZTS3

Across TCGA cell cohorts, LZTS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,357 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible LZTS3-associated GO terms across cancer lineages are Regulation of protein localization to endoplasmic reticulum, Positive regulation of protein localization to endoplasmic reticulum, and Positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Each is linked with LZTS3 in more than 11 cancer types. Because this analysis shows association rather than direction, both LZTS3-to-partner and partner-to-LZTS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to endoplasmic reticulum grouped by LZTS3-low versus LZTS3-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LZTS3→partner) and Y-score (partner→LZTS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of protein localization to endoplasmic reticulum →	+0.105	+1.422	<.001	.001	3	12
OVARY	Positive regulation of protein localization to endoplasmic reticulum →	+0.110	+1.481	<.001	<.001	2	12
BONE	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.070	+0.840	<.001	.004	3	10
STOMACH	Virion assembly →	+0.085	+1.482	.002	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Vacuole organization →	+0.048	+1.008	<.001	<.001	3	10
BONE	Regulation of protein localization to nucleus →	+0.083	+1.392	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,357 associations by consensus.

Regulation of protein localization to endoplasmic reticulum by LZTS3 expression — OVARY

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