LZTS2

Across TCGA patient cohorts, LZTS2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LZTS2-associated genes across cancer lineages are eIF4E, JNK2, and MEK1. Each is linked with LZTS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LZTS2-to-partner and partner-to-LZTS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by LZTS2-low versus LZTS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LZTS2→partner) and Y-score (partner→LZTS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.210	+3.013	.013	.018	3	1
UCEC	JNK2 →	+0.174	+2.834	.029	.034	3	1
UCEC	MEK1 →	+0.311	+2.584	.034	.010	3	1
UCEC	Notch1 →	+0.121	+2.331	.032	.019	3	1
UCEC	p62 Lck ligand →	+0.475	+2.009	<.001	.017	3	1
UCEC	P-Cadherin →	-0.136	-1.893	.019	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

eIF4E by LZTS2 expression — UCEC

Explore this box plot interactively →