LZTS2

Across TCGA cell cohorts, LZTS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,481 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LZTS2-associated GO terms across cancer lineages are Viral translational termination-reinitiation, Pre-mRNA catabolic process, and Positive regulation of neuron migration. Each is linked with LZTS2 in more than 16 cancer types. Because this analysis shows association rather than direction, both LZTS2-to-partner and partner-to-LZTS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral translational termination-reinitiation grouped by LZTS2-low versus LZTS2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LZTS2→partner) and Y-score (partner→LZTS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Viral translational termination-reinitiation →	+0.096	+1.358	<.001	<.001	3	17
SKIN	Pre-mRNA catabolic process →	+0.155	+0.970	<.001	<.001	3	14
STOMACH	Positive regulation of neuron migration →	+0.101	+1.194	.005	<.001	3	14
LARGE_INTESTINE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.168	+1.235	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.125	+1.080	<.001	.001	3	14
SOFT_TISSUE	Negative regulation of chromosome organization →	+0.073	+1.063	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,481 associations by consensus.

Viral translational termination-reinitiation by LZTS2 expression — LARGE_INTESTINE

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