LZTS2

Across TCGA cell cohorts, LZTS2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. CNS shows the largest number of these associations.

The most reproducible LZTS2-associated genes across cancer lineages are GHRHR, MAGEB5, and PRR23A. Each is linked with LZTS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LZTS2-to-partner and partner-to-LZTS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRHR grouped by LZTS2-low versus LZTS2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LZTS2→partner) and Y-score (partner→LZTS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GHRHR →	+0.176	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LUNG_SCLC	PRR23A →	+0.038	+5.029	<.001	.006	3	1
BLOOD_Leukemia	OR10R2 →	+1.283	+4.551	.006	.004	3	1
CNS	GPR6 →	+0.052	+4.981	<.001	.008	3	1
CNS	TEX55 →	+0.049	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GHRHR by LZTS2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →