LZIC

Across TCGA patient cohorts, LZIC mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LZIC-associated genes across cancer lineages are RNA5SP405, SNORA36C, and TRAJ21. Each is linked with LZIC in more than 1 cancer types. Because this analysis shows association rather than direction, both LZIC-to-partner and partner-to-LZIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP405 grouped by LZIC-low versus LZIC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LZIC→partner) and Y-score (partner→LZIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP405 →	+0.378	+3.997	<.001	.009	3	1
UCEC	SNORA36C →	+0.334	+3.814	<.001	.002	3	1
UCEC	TRAJ21 →	+0.700	+3.351	<.001	.003	3	1
UCEC	TRAJ5 →	+1.097	+2.832	<.001	.007	3	1
UCEC	RNU6-1228P →	+0.213	+4.464	.003	.005	3	1
UCEC	RNU6-482P →	+0.441	+3.294	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

RNA5SP405 by LZIC expression — UCEC

Explore this box plot interactively →