LZIC

Across TCGA cell cohorts, LZIC mutation is significantly associated with the RNA expression of many other genes, with 190 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LZIC-associated genes across cancer lineages are CCDC134, CBX7, and FZR1. Each is linked with LZIC in more than 1 cancer types. Because this analysis shows association rather than direction, both LZIC-to-partner and partner-to-LZIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC134 grouped by LZIC-low versus LZIC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LZIC→partner) and Y-score (partner→LZIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC134 →	+0.826	+3.131	.001	.008	3	1
LARGE_INTESTINE	CBX7 →	+0.942	+3.212	.001	.006	3	1
LARGE_INTESTINE	FZR1 →	+0.684	+3.299	.007	.004	3	1
LARGE_INTESTINE	MSH3 →	+0.530	+3.212	.009	.006	3	1
LARGE_INTESTINE	LDLR →	+0.855	+3.212	.003	.006	3	1
LARGE_INTESTINE	GCH1 →	+0.571	+3.212	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 190 associations by consensus.

CCDC134 by LZIC expression — LARGE_INTESTINE

Explore this box plot interactively →