LYZ

Across TCGA patient cohorts, LYZ mutation is significantly associated with the RNA expression of many other genes, with 66 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible LYZ-associated genes across cancer lineages are MIR4510, RN7SL248P, and TTTY2. Each is linked with LYZ in more than 1 cancer types. Because this analysis shows association rather than direction, both LYZ-to-partner and partner-to-LYZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4510 grouped by LYZ-low versus LYZ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYZ→partner) and Y-score (partner→LYZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4510 →	+0.297	+4.453	<.001	.006	3	2
UCEC	RN7SL248P →	+0.139	+4.722	<.001	.004	3	2
HNSC	TTTY2 →	+0.014	+7.954	<.001	.008	3	2
SKCM	MIR133B →	+0.886	+5.408	<.001	.002	3	2
UCEC	MIR5708 →	+0.422	+4.877	<.001	.003	3	1
SKCM	PCDH9-AS1 →	+0.058	+4.743	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

MIR4510 by LYZ expression — UCEC

Explore this box plot interactively →