LYVE1

Across TCGA patient cohorts, LYVE1 mutation is significantly associated with the RNA expression of many other genes, with 648 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYVE1-associated genes across cancer lineages are BRD9P1, RN7SKP46, and HSPE1P4. Each is linked with LYVE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYVE1-to-partner and partner-to-LYVE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRD9P1 grouped by LYVE1-low versus LYVE1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYVE1→partner) and Y-score (partner→LYVE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BRD9P1 →	+0.060	+4.392	<.001	.006	3	2
UCEC	RN7SKP46 →	+0.088	+4.276	<.001	.005	3	2
SKCM	HSPE1P4 →	+0.336	+3.274	.001	.008	3	2
SKCM	E2F7 →	+0.889	+3.331	<.001	.005	3	2
UCEC	PLCB3 →	+0.545	+3.332	.003	.005	3	2
UCEC	H3C8 →	+0.906	+3.467	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 648 associations by consensus.

BRD9P1 by LYVE1 expression — COAD

Explore this box plot interactively →