LYST

Across TCGA cell cohorts, LYST mutation is significantly associated with the RNA expression of many other genes, with 2,419 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LYST-associated genes across cancer lineages are EDEM1, KHDC3L, and ARL5C. Each is linked with LYST in more than 3 cancer types. Because this analysis shows association rather than direction, both LYST-to-partner and partner-to-LYST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EDEM1 grouped by LYST-low versus LYST-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYST→partner) and Y-score (partner→LYST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EDEM1 →	+0.606	+2.526	<.001	.002	3	4
BLOOD_Leukemia	KHDC3L →	+0.117	+1.996	<.001	.007	3	3
LUNG_SCLC	ARL5C →	+0.157	+3.570	<.001	<.001	3	3
SOFT_TISSUE	PRAC1 →	+3.348	+3.551	<.001	.004	3	3
BREAST	NCAPG2 →	+0.847	+3.206	.003	.003	3	3
BREAST	MCM6 →	+0.677	+3.473	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,419 associations by consensus.

EDEM1 by LYST expression — LARGE_INTESTINE

Explore this box plot interactively →