LYST-AS1

Across TCGA pan-cancer cohorts, LYST-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated LYST-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LYST-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated LYST-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LAML show a favorable association.

HNSC, LAML, and LUSC are the cancer types where LYST-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.746	0.635	.003	52	view →
LAML	DFS	Median	All	0.737	0.409	.001	36	view →
LUSC	DFS	Tertile	III,IV	0.197	0.865	<.001	36	view →
KICH	DFS	Quartile	III,IV	0.052	0.908	<.001	33	view →
STAD	OS	Median	II,III,IV	0.492	0.341	.006	32	view →
UVM	DFS	Tertile	III,IV	0.282	0.600	.020	18	view →
THCA	OS	Tertile	II,III,IV	0.666	0.965	.005	17	view →
KIRC	OS	Tertile	All	0.572	0.701	.021	14	view →
COAD	DFS	Tertile	II,III,IV	0.803	0.634	.029	9	view →
MESO	OS	Tertile	III,IV	0.195	0.582	.034	9	view →
LGG	OS	Quartile	All	0.712	0.854	.010	9	view →
KIRP	OS	Tertile	All	0.903	0.959	.029	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

LYST-AS1–HNSC (DFS)

Open the HNSC breakdown →